![]() ![]() Researchers have also expressed magnolia extract’s potential as an effective management tool for menopause symptoms in women. Studies suggest that honokiol’s neuroprotective properties make it a viable candidate for treating neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. However, there are no studies on human subjects. Medical researchers found that in mice studies, honokiol increases GABA neurotransmitter synthesis in the hippocampal regions in the brain ( x). Additionally, studies show that a blend of honokiol and magnolol may reduce corticosterone concentration in the brain, which is associated with symptoms of depression ( x). The same study also found that honokiol is effective at combating the anxiety-producing effects of large doses of caffeine ( x). One particular study found that an active dose as small as 0.2 mg/kg can possibly significantly increase exploratory behavior and decrease anxiety-related behavior in animal models. Thus, honokiol is more selective in the receptors it binds to, which enables it to produce a similar anxiolytic effect with fewer detrimental side effects. However, honokiol has fewer motor and cognitive side effects than traditional anxiety medications, such as Xanax and Klonopin. Researchers believe that honokiol acts on GABA receptors in the brain in a similar manner to benzodiazepines and Z-drugs ( x). ![]() Magnolia extract may also have connection with anxiety. Studies show that both honokiol and magnolol may have potent antimicrobial effects and have the potential to treat periodontal pathogens ( x). Many separate studies have verified that toothpaste and gum that contains magnolia extract reduces the amount of gingivitis on the gums and kills bacteria that cause bad breath ( x, x). Magnolia extract may be effective at combating gingivitis and bad breath. Benefits of Magnolia Extractīecause the two active components in magnolia extract can influence many different pathways in the body, magnolia extract may present a diverse set of benefits against the several different conditions. Specifically, honokiol can readily cross the blood-brain and the blood-cerebrospinal fluid barriers, which makes it a potent therapy with high bioavailability ( x). Clinical studies describe honokiol and magnolol as pleiotropic compounds, meaning that they can affect the body through a number of chemical pathways. There are two active compounds in magnolia extract responsible for the bulk of its beneficial properties - honokiol and magnolol, two types of compounds called lignans. Magnolia extract is used to address several common ailments, such as nasal congestion, indigestion, inflammation, anxiety, headaches, sinus pain, toothaches and sleep disturbances. There is a growing body of evidence that it may act as an effective anti-inflammatory, antioxidant, antithrombotic and anti-tumorigenic agent. Magnolia extract apparently offers several beneficial properties. In traditional Chinese medicine, magnolia bark is called “houpu” and it is a very common ingredient ( x). Magnolia has a long history as a traditional medicine and for its therapeutic properties. The extract is made with an oil infusion method that steeps crushed and scraped plant material in an oil solution. Magnolia extract is a medicinal compound from the bark and flower buds of the magnolia tree. One recent candidate for a viable medicinal plant is magnolia. Did you know that most common drugs and medicine derived from plants? It is true - of the top 150 prescribed drugs in the United States, at least 118 of them have active components derived from natural sources ( x). ![]()
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